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COULD CATTLE                                        The Midwest Cattleman · September 14, 2023 · P14
        Tulieve                          continued from page 12
                     ®
        (tulathromycin injection)
        Injectable Solution              from the survey. And the ex-
        Antibiotic                       pected corn prices in the next
        100 mg of tulathromycin/mL       18 months ahead over the last
        For use in beef cattle (including suckling calves), non-lactating dairy cattle
        (including dairy calves), veal calves, and swine. Not for use in female dairy   three surveys certainly show
        cattle 20 months of age or older.  a downward trend in what
        CAUTION: Federal (USA) law restricts this drug use by or on the order of a
        licensed veterinarian.           folks expect on the corn side,"
        DESCRIPTION:                     says Brown.
        Tulieve® Injectable Solution is a ready-to-use sterile parenteral preparation
        containing tulathromycin, a semi-synthetic macrolide antibiotic of the   Economists say the biggest
        subclass triamilide. Each mL of Tulieve contains 100 mg of tulathromycin,   impacts  on  crop  prices  will
        500 mg propylene glycol, 19.2 mg citric acid and 5 mg monothioglycerol.
        Sodium hydroxide or hydrochloric acid may be added to adjust pH.  come from:
        Tulieve consists of an equilibrated mixture of two isomeric forms of
        tulathromycin in a 9:1 ratio.       •Demand domestically (in-
        The chemical names of the isomers are (2R,3S,4R,5R,8R,10R,11R,12S,13S,   cluding  for  feed  grains)  and
        14R)-13-[[2,6-dideoxy-3-C-methyl-3-Ο-methyl-4-C-[(propylamino) methyl]-
        α-L-ribo-hexopyrano-syl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-   abroad (particularly in China)
        hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]-   commodities, the ag economy  sponded to the question.
        oxy]-1-oxa-6-azacyclopentadecan-15-one and (2R,3R,6R,8R,9R,10S,11S,   •War in the Black Sea if
        12R)-11-[[2,6-dideoxy-3-C-methyl-3-Ο-methyl-4-C-[(propylamino)methyl]-   has been resilient."            "The current most-import-
        α-L-ribo-hexopyrano-syl]oxy]-2-[(1R,2R)-1,2-dihydroxy-1-methylbutyl]-   shipments from Russia are      ant factors are weather and
        8-hydroxy-3,6,8,10,12-pentamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-
        β-D-xylo-hexopyranosyl]oxy]-1-oxa-4- azacyclotridecan-13-one, respectively.   curtailed  What Will Drive the Ag   input costs. In one year from
        INDICATIONS                         •El Nino presence and
        Beef and Non-Lactating Dairy Cattle                                 Economy Over the Next 12  now, it will be Brazilian pro-
        BRD-Tulieve Injectable Solution is indicated for the treatment of bovine   weather in major crop produc-  Months?   duction policy," says another
        respiratory disease (BRD) associated with Mannheimia haemolytica,   tion areas of the world
        Pasteurella multocida, Histophilus somni, and Mycoplasma bovis; and for the   The  economists  turned economist.
        control of respiratory disease in cattle at high risk of developing BRD   •Strong  competition  in
        associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus   more bullish on livestock in   "Agriculture is benefiting
        somni, and Mycoplasma bovis.     the international corn export
        IBK-Tulieve Injectable Solution is indicated for the treatment of infectious   the latest survey, while the  from  somewhat lower  input
        bovine keratoconjunctivitis (IBK) associated with Moraxella bovis.   market and U.S. export levels  outlook for corn prices pro- prices, but weather is creat-
        Foot Rot-Tulieve Injectable Solution is indicated for the treatment of   •U.S. crop acreage stable,
        bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium   duced more pessimism. But  ing challenges in production.
        necrophorum and Porphyromonas levii.   better yields pushing down
        Suckling Calves, Dairy Calves, and Veal Calves                      economists continue to be im- During the next 12 months
        BRD-Tulieve Injectable Solution is indicated for the treatment of BRD   prices
        associated with M. haemolytica, P. multocida, H. somni, and M. bovis.  pressed with how farmers and  production  costs should con-
        Swine                                                               ranchers have withstood high- tinue to moderate, but prices
        Tulieve Injectable Solution is indicated for the treatment of swine   Overall Outlook for the Ag
        respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae,   er costs on their operation.     are also moderating so that
        Pasteurella multocida, Bordetella bronchiseptica, Haemophilus parasuis, and   Economy
        Mycoplasma hyopneumoniae; and for the control of SRD associated with   "The  financial  strength  on  the net change is slightly pos-
        Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma   Brown says the month-  many farms is rather strong  itive. A new farm bill needs to
        hyopneumoniae in groups of pigs where SRD has been diagnosed.   ly survey shows economists'
        DOSAGE AND ADMINISTRATION                                           and many have taken advan- be completed to create more
        Cattle                           views of the ag economy ha-
        Inject subcutaneously as a single dose in the neck at a dosage of  2.5 mg/kg   tage of relatively high pric- certainty and reduce reve-
        (1.1 mL/100 lb) bodyweight (BW). Do not inject more than 10 mL per   ven't changed much in the   es for crops and cattle. Hogs  nue risk," is another response
        injection site.                  three months  of conducting
        Swine                                                               and poultry are in somewhat  from the anonymous survey.
        Inject intramuscularly as a single dose in the neck at a dosage of 2.5 mg/kg   the  survey. The August  data
        (0.25 mL/22 lb) BW. Do not inject more than 2.5 mL per injection site.  worse shape now than last
        CONTRAINDICATIONS                show economists are:               year. Looking ahead, I expect  Projecting the Positives
        The use of  Tulieve Injectable Solution is contraindicated in animals   •5%  less  optimistic  about
        previously found to be hypersensitive to the drug.                  that lower crop prices and  Pieces for the Ag Economy
        WARNINGS                         the health of the ag economy       stable input prices will put a       With so much concern about
        FOR USE IN ANIMALS ONLY.         a year from now relative to
        NOT FOR HUMAN USE.                                                  squeeze on high-cost crop pro- international competition and
        KEEP OUT OF REACH OF CHILDREN.   today
        NOT FOR USE IN CHICKENS OR TURKEYS.                                 ducers. Consolidation across  domestic demand, economists
          RESIDUE WARNINGS                  •10% less optimistic when       all of agriculture is something  also pointed out some posi-
          Cattle                         looking at the ag economy
          Cattle intended for human consumption must not be slaughtered     I expect to be a theme in the  tives in the ag economy, in-
          within 18 days from the last treatment. This drug is not approved for   today versus 12 months ago    year ahead," says one ag econ- cluding farmland values and
          use in female dairy cattle 20 months of age or older, including dry
          dairy cows. Use in these cattle may cause drug residues in milk and/or   "I think the biggest thing   omist in the anonymous sur- the U.S. economy.
          in calves born to these cows.  to note is just how resilient
          Swine                                                             vey.                                 •"The land value market
          Swine intended for human consumption must not be slaughtered   we've been.  And that shows
          within 5 days from the last treatment.                              "We're seeing an explosion  has a lot of supportive fun-
        PRECAUTIONS                      in some of the answers we got      of   competitive     production damentals under it and will
        Cattle                           back  from  the economists,"
        The e ects of tulathromycin injection on bovine reproductive performance,   coming out of Brazil at the  withstand a couple years of
        pregnancy, and lactation have not been determined. Subcutaneous   says Brown. "Although there's   same time that geopolitical  negative farm income. As a re-
        injection can cause a transient local tissue reaction that may result in trim
        loss of edible tissue at slaughter.   been lots of concern about con-  risks are increasing in a world  sult, farm balance sheets will
        Swine                            sumer demand  and interna-
        The e ects of tulathromycin injection on porcine reproductive performance,   facing mounting credit risks,"  stay rather healthy and those
        pregnancy, and lactation have not been determined. Intramuscular   tional demand for a lot of our
        injection can cause a transient local tissue reaction that may result in trim   was how one economist re- that  have available working
        loss of edible tissue at slaughter.                                                                   capital and cash will be posi-
        ADVERSE REACTIONS
        Cattle                                                                                                tioned well,"  says one econo-
        In one BRD  eld study, two calves treated with tulathromycin injection at                             mist.
        2.5 mg/kg BW exhibited transient hypersalivation. One of these calves also
        exhibited transient dyspnea, which may have been related to pneumonia.                                   •"At  least  so  far,  the  U.S.
        Swine
        In one  eld study, one out of 40 pigs treated with tulathromycin injection at                         economy has proven more re-
        2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours.                         silient in 2023 than many had
        Approved by FDA under ANADA # 200-723                                                                 anticipated," was another re-
        Tulieve® is a registered trademark of Norbrook Laboratories Limited
        Made in the UK                                                                                        sponse in the monthly survey.
        Manufactured by:                                                                                         •"Lower fertilizer costs and
        Norbrook Laboratories Limited, Newry, BT35 6PU, Co. Down,
        Northern Ireland                                                                                      a relatively stable U.S. econo-
        To report suspected adverse drug events, for technical assistance or to                               my," says another economist.
        obtain a copy of the Safety Data Sheet (SDS), contact Norbrook at
        1-866-591-5777. For additional information about adverse drug                                            •"I see strong international
        experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or
        http://www.fda.gov/reportanimalae.                                                                    markets for pork and beef as
        Revised Feb 2022                                                                                      the most positive aspect re-
        For additional Tulieve                                                                                garding the outlook of U.S. ag-
        product information call:
        1-866-591-5777 or go to                                                                               riculture," one economist says.
        NorbrookFA.com/Tulieve
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